Quinivir 200mg Tablet

✔️ Uses of Quinivir 200mg Tablet

Type 2 diabetes mellitus, acute or chronic rheumatoid arthritis, dyslipidemia, systemic and discoid lupus erythematosus, polymorphous light eruption, and malaria.

✔️ Side Effects of Quinivir 200mg Tablet

• Blurred vision
• Abdominal pain
• Nausea
• Vomiting
• Loss of appetite
• Diarrhea
• Headache
• Mood changes
• Skin rashes
• Itching
• Sensitivity to light
• Pigmentation disorders

✔️ How does Quinivir 200mg Tablet work?

Type 2 Diabetes Mellitus:

• Improves insulin sensitivity
• Increases insulin secretion

Rheumatoid Arthritis:

• Acts as a mild immunosuppressant
• Disease-modifying anti-rheumatic agent
• Inhibits the production of rheumatoid factor

Systemic and Discoid Lupus Erythematosus:

• Decreases the severity of skin lesions

Malaria:

• Increases the concentration of a toxic compound in the parasite, leading to its death

✔️ Quick Suggestions:

• Consume Hydroxychloroquine with food to prevent an upset stomach.
• It may take 8-12 weeks for Hydroxychloroquine to show its therapeutic effects. It's important to continue taking it as prescribed by your healthcare provider.
• Do not take medicines that neutralize stomach acids (antacids) four hours before and after taking Hydroxychloroquine. This precaution is necessary to ensure proper absorption of the medicine from your gut.
• Undergo regular eye tests while taking Hydroxychloroquine. Monitoring your vision is crucial, and any changes should be promptly reported to your doctor.
• Be aware of symptoms of low blood glucose levels (hypoglycemia), such as cold sweats, cool pale skin, tremors, and anxious feelings. Inform your doctor immediately if you experience these symptoms.

✔️ Indications:

• Type 2 diabetes mellitus
• Acute or chronic rheumatoid arthritis
• Dyslipidaemia (elevated cholesterol levels)
• Systemic and discoid lupus erythematosus (autoimmune disease)
• Polymorphous light eruption (rash caused by sun exposure)
• Malaria

✔️ Pharmacology

• Suppresses immune system
• Accumulates in white blood cells
• Kills growing parasites by breaking cell walls

✔️ Dosage & Administration of Quinivir 200mg Tablet

Adult Dose:

Oral Malaria:

• Acute treatment: 800 mg PO, then 400 mg PO 6-8 hours later, then 400 mg PO at 24 and 48 hours.
• Prophylaxis: 400 mg PO weekly, starting 2 weeks before exposure and continuing for 4 weeks after departure from the area.

Rheumatoid Arthritis:

• Initial dose: 400-600 mg PO daily for 4-12 weeks.
• Maintenance: 200-400 mg PO daily.

Systemic Lupus Erythematosus:

• Initial dose: 400 mg PO once or twice daily.
• Maintenance: 200-400 mg PO daily.

Hepatic Impairment:

• Estimation of plasma hydroxychloroquine levels to be undertaken in patients with severely compromised function and dosage adjusted accordingly.

Child Dose:

Malaria:

• Acute treatment: 13 mg/kg base PO, then 6.5 mg/kg base PO 6 hr later, then 6.5 mg/kg base PO at 24 and 48 hours; not to exceed 400 mg/day base.
• Prophylaxis: 6

.5 mg/kg base (not to exceed 400 mg [310 mg base]) PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from the area.

Renal Dose:

• In cases of renal impairment, estimation of plasma hydroxychloroquine levels should be undertaken in patients with severely compromised function, and dosage adjusted accordingly.

✔️ Interaction

Drug-Drug Interaction:

• Interactions with anti-cancer drugs, heart-related medicines, anti-diabetic drugs, anti-malarial drugs, antibiotics, immunosuppressants, heartburn medicines, antipsychotics, fits medicines, and anticoagulants are mentioned.

Drug-Food Interaction:

• It is advised to avoid alcohol consumption while using Quinivir 200mg Tablet.

Drug-Disease Interaction:

• The importance of informing the doctor about medical history is emphasized, including conditions like liver or kidney problems, heart diseases, diabetes, G-6-PD deficiency, high blood pressure, serious stomach or gut problems, nervous system problems, psoriasis, porphyria, history of heart attack, electrolyte imbalance, fits, damaged retina or vision problems, and allergic reactions to medicines.

✔️ Contraindications

• Retinal or visual changes
• Hypersensitivity to 4-aminoquinoline compounds
• Long-term therapy in children

✔️ Pregnancy & Lactation

• Take during pregnancy only if necessary
• If detected in minute levels in breast milk, consult with the doctor before use

✔️ Precautions & Warnings

• Inform your doctor about allergies, liver/kidney/heart diseases, gastrointestinal problems, blood disorders, and brain-related problems.
• Pregnant and breastfeeding women should consult their doctor before use.
• May cause blurred vision; avoid driving or operating machinery until you feel better.

✔️ Storage Conditions

Store below 30°C, protected from light & moisture. Keep out of reach of children.